NCBI-Aggregator

Development and validation of a machine learning model to detect psychiatric symptoms in Huntington's disease using speech analysis

PLoS One. 2026 Jul 1;21(7):e0350118. doi: 10.1371/journal.pone.0350118. eCollection 2026.ABSTRACTHuntington's disease (HD) causes progressive disability through motor, psychiatric, and cognitive symptoms. Machine learning speech analysis can detect motor and cognitive symptoms of HD, but not yet psychiatric symptoms. This study investigated whether speech analyses can detect the presence of psychiatric symptoms...Read more

Source: NCBI Date: 2026-07-01 By Quang Tuan Rémy Nguyen
Topological modeling of gene expression in the brain with Huntington's disease reveals selective disruption of co-expression network

Sci Rep. 2026 Jun 30;16(1):18328. doi: 10.1038/s41598-026-56101-8.ABSTRACTWe applied transcriptome tomography to create a whole-brain model of early-stage Huntington's disease (HD) in R6/2 mice, which ubiquitously express truncated human mutant HTT containing approximately 150 CAG repeats. Medium spiny neuron (MSN)-related genes showed abnormal expression in the HD brain, in terms of...Read more

Source: NCBI Date: 2026-06-30 By Yuko Okamura-Oho
Childhood to Adult Neurodevelopment in Gene-Expanded Huntington's Disease (ChANGE-HD): A prospective longitudinal neurodevelopmental study of Huntington's disease

PLoS One. 2026 Jun 25;21(6):e0336088. doi: 10.1371/journal.pone.0336088. eCollection 2026.ABSTRACTAlthough adult Huntington's disease (HD) studies have significantly advanced our understanding of the course of degeneration, they may underrepresent critical neurodevelopmental aspects of the disease. Significant gaps remain in understanding how mutant huntingtin affects early neurodevelopment, its long-term impact, as well as...Read more

Source: NCBI Date: 2026-06-25 By Mohit Neema
Progressive Huntington's disease with neuropsychiatric predominance across fragmented care settings

BMJ Case Rep. 2026 Jun 23;19(6):e273348. doi: 10.1136/bcr-2026-273348.ABSTRACTHuntington's disease (HD) is characterised by progressive motor impairment and neuropsychiatric dysfunction; however, early presentations may be dominated by psychiatric symptoms. We describe a man in his 50s with a documented diagnosis of HD established several years prior and a strong family history,...Read more

Source: NCBI Date: 2026-06-23 By Gregory Michael Tomlinson
Effect of Deuterated Drugs on Safety: Insights from Pharmacovigilance Data Analysis

Biol Pharm Bull. 2026;49(6):983-988. doi: 10.1248/bpb.b25-00768.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. Tetrabenazine (TBZ), a vesicular monoamine transporter 2 inhibitor, is commonly used to manage chorea; however, it may exhibit fluctuating plasma levels and elicit frequent adverse events. In this study, we...Read more

Source: NCBI Date: 2026-06-21 By Kohei Kitagawa
Speech and swallowing rehabilitation in Huntington's disease: clinical outcomes and correlations with disease severity

Neurol Sci. 2026 Jun 19;47(7):576. doi: 10.1007/s10072-026-09179-x.ABSTRACTINTRODUCTION: Corticobulbar symptoms, including dysarthria and dysphagia, are frequent manifestations of Huntington's disease, yet evidence on speech and swallowing rehabilitation remains limited. This study explored the potential effects of a home-based corticobulbar rehabilitation program on selected speech and swallowing-related clinical outcomes in Huntington's disease.METHODS:...Read more

Source: NCBI Date: 2026-06-19 By Tuğçe Saltoğlu
Development and validation of the first needs-based quality of life measure for individuals with manifest Huntington's disease

J Neurol. 2026 Jun 11;273(7):391. doi: 10.1007/s00415-026-13898-8.ABSTRACTBACKGROUND: Huntington's disease (HD) is a progressive, hereditary neurodegenerative disorder currently without curative treatments, thus making quality of life (QoL) an important outcome for clinical care and therapeutic evaluation. Existing HD-specific patient-reported outcome measures (PROMs) do not adequately capture the experiences of individuals with...Read more

Source: NCBI Date: 2026-06-11 By Isobel Spray
Mitochondrial Dysfunction as a Driver of Neurodegeneration in Parkinson's and Huntington's Disease: Molecular Insights and Emerging Interventions

Mol Neurobiol. 2026 Jun 10;63(1):685. doi: 10.1007/s12035-026-05991-w.ABSTRACTMitochondrial dysfunction has emerged as a central contributor to the pathogenesis of major neurodegenerative disorders, such as Parkinson's and Huntington's disease. In Parkinson's disease, mitochondrial abnormalities are often linked to mutations in genes like PINK1 and Parkin, which regulate mitochondrial quality control, while α-synuclein...Read more

Source: NCBI Date: 2026-06-10 By Omkar Kumar Kuwar
Regulation of huntingtin-polyQ aggregation by glucose transporters and saccharide-binding receptors during aging in Drosophila

J Gerontol A Biol Sci Med Sci. 2026 Jul 1;81(8):glag153. doi: 10.1093/gerona/glag153.ABSTRACTSaccharides and responsive signaling pathways are important regulators of physiological and pathological processes. Saccharides can exert these functions via dedicated intracellular transporters and through binding to cellular sensors, such as saccharide-binding receptors. Glucose homeostasis and saccharide signaling are emerging...Read more

Source: NCBI Date: 2026-06-06 By Mamta Rai
Counseling patients in the predictive genetics clinic for Huntington's disease: A qualitative analysis of ethnographic observations

J Genet Couns. 2026 Jun;35(3):e70240. doi: 10.1002/jgc4.70240.ABSTRACTLittle research has been conducted on patients' experiences inside the predictive genetics clinic. In this clinic, a person with a familial risk of inheriting a rare disease seeks a test that will provide them with information about their future health. Counselors combine gentle challenges...Read more

Source: NCBI Date: 2026-06-04 By Shane Doheny
3-Nitropropionic Acid-Induced Huntington's Disease in Preclinical Models: Mechanisms, Peripheral Toxicities, Model Gaps, and Future Directions

Mol Neurobiol. 2026 May 30;63(1):662. doi: 10.1007/s12035-026-05967-w.ABSTRACTHuntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by an expanded cytosine-adenine-guanine (CAG) repeat (> 36 repeats) in the huntingtin gene, leading to progressive motor dysfunction, cognitive decline, and psychiatric disturbances. Despite extensive research, the precise pathophysiological mechanisms underlying HD remain incompletely...Read more

Source: NCBI Date: 2026-05-30 By Harikrishna Reddy Dontiboina
Neuroprotective Potential of Pinostrobin in a Rat Model of Huntington's Disease: Behavioural, Biochemical, and Molecular Docking Evidence

Mol Neurobiol. 2026 May 29;63(1):660. doi: 10.1007/s12035-026-05946-1.ABSTRACTHuntington's disease (HD) is an enormously destructive autosomal hereditary neurodegenerative disease that results in malfunction of motor, psychological, and cognitive deficits. The neurotoxin 3-nitropropionic acid (3-NPA) is known to induce HD-like signs in the in vivo rat model. The current research is aimed at...Read more

Source: NCBI Date: 2026-05-29 By Sami I Alzarea
Transposable element small RNAs and large RNAs in aging brains and implications in Huntington's and Parkinson's disease

Genome Res. 2026 Jun 1;36(6):1125-1140. doi: 10.1101/gr.280565.125.ABSTRACTTransposable elements (TEs) are implicated in aging and neurodegenerative disorders, but the impact on brain TE RNA dynamics in these phenomena is not fully understood. Therefore, we quantify TE RNA changes in aging postmortem human and mouse brains and in the neurodegenerative disorders Huntington's...Read more

Source: NCBI Date: 2026-05-28 By Gargi Dayama
Striatal Neuron Excitability Is Regulated by Huntingtin in the Adult Brain

eNeuro. 2026 Jun 9;13(6):ENEURO.0269-25.2026. doi: 10.1523/ENEURO.0269-25.2026. Print 2026 Jun.ABSTRACTHuntington's disease (HD) is a hereditary neurodegenerative disease that typically presents during midlife and is characterized by a combination of motor, cognitive, and psychiatric symptoms. HD is fatal and arises from a mutation in the huntingtin (HTT) gene, which results in decreased...Read more

Source: NCBI Date: 2026-05-28 By Jessica C Barron
Large scale functional and effective connectivity alterations cross the Huntington's disease integrated staging system

Neuroimage Clin. 2026;50:104009. doi: 10.1016/j.nicl.2026.104009. Epub 2026 May 19.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative disease with severe motor, cognitive and behavioral symptoms. There is a recent impetus to develop treatments that slow progression before clinical signs emerge. Such early interventions require biomarkers sensitive to the very earliest HD progression....Read more

Source: NCBI Date: 2026-05-27 By Murat Demirtas

…