NCBI-Aggregator

J Genet Couns. 2026 Jun;35(3):e70230. doi: 10.1002/jgc4.70230.ABSTRACTMany individuals affected by the hereditary neurological condition Huntington's disease (HD) have reported experiences of stigmatization, yet the extant literature is currently theoretically and methodologically underdeveloped. Therefore, this scoping review aimed to examine the methodological approaches and theoretical conceptualizations of stigma used and to...Read more

J Genet Couns. 2026 Jun;35(3):e70217. doi: 10.1002/jgc4.70217.ABSTRACTThe Huntington's Disease Society of America (HDSA) protocol requires in-person result disclosure for predictive testing due to the increased suicidality risk in the Huntington's disease (HD) population. The 21st Century Cures Act (Cures), a United States law requiring immediate release of all healthcare test...Read more

Dis Model Mech. 2026 Jun 1;19(6):dmm052585. doi: 10.1242/dmm.052585. Epub 2026 May 11.ABSTRACTHuntington's disease (HD) is a neurodegenerative autosomal dominant hereditary disease caused by a CAG triplet repeat expansion mutation in the gene encoding the huntingtin (HTT) protein. The main feature of HD is the loss of striatal neurons, accompanied by...Read more

Eur J Pharmacol. 2026 May 28;1025:178916. doi: 10.1016/j.ejphar.2026.178916. Epub 2026 May 1.ABSTRACTHuntington's disease (HD)-associated depression is a prevalent psychiatric symptom affecting between one-third and over two-thirds of patients, significantly impacting their quality of life. Agmatine, a biogenic amine produced by the decarboxylation of L-arginine, has recently garnered attention for its...Read more

Laeknabladid. 2026 May;112(5):216-222. doi: 10.17992/lbl.2026.05.891.ABSTRACTHuntington's disease (HD) is a rare, autosomal dominant neurodegenerative disorder characterized by progressive movement disturbances, psychiatric symptoms, and cognitive impairment. The disease is caused by an increased number of repeats of the cytosine-adenine-guanine (CAG) base sequence in the HTT gene, leading to the production of a...Read more

Neurobiol Dis. 2026 Jun 15;224:107413. doi: 10.1016/j.nbd.2026.107413. Epub 2026 Apr 25.ABSTRACTHuntington's disease is a multisystemic neurodegenerative disorder for which increasing evidence suggests early involvement of brain regions beyond the primarily affected motor areas of the brain, such as the olfactory bulb, which is affected by multiple neurodegenerative diseases. However, the...Read more

Artif Cells Nanomed Biotechnol. 2026 Dec;54(1):316-331. doi: 10.1080/21691401.2026.2644164. Epub 2026 Apr 24.ABSTRACTAlzheimer's disease (AD) and Huntington's disease (HD) share neuroinflammatory mechanisms, yet their specific immune microenvironments remain poorly understood. Integrating transcriptomic profiles of peripheral blood and frontal cortex tissues with 2,160 immune-related genes, we analysed their shared immunopathology. Differential analysis...Read more

Psychol Health. 2026 May;41(5):674-695. doi: 10.1080/08870446.2025.2474010. Epub 2025 Mar 6.ABSTRACTOBJECTIVE: Irritability has been reported as a common psychological co-occurrence with Huntington's disease (HD). Irritability associated with HD is variously attributed to neurological changes, an understandable response to increasing difficulties with cognition and communication, or a multifactorial combination of the two...Read more

Neurobiol Dis. 2026 Jun 15;224:107411. doi: 10.1016/j.nbd.2026.107411. Epub 2026 Apr 22.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative disorder that leads to thbe production of pathogenic mutant huntingtin (mHtt) protein and is characterized by motor and psychiatric symptoms. While HD has classically been studied as a brain-centered condition, emerging research indicates...Read more

J Neurol. 2026 Apr 21;273(5):285. doi: 10.1007/s00415-026-13825-x.ABSTRACTOBJECTIVE: Apathy is a common and debilitating neuropsychiatric symptom in Huntington's disease (HD), yet its long-term trajectory remains poorly characterized. This study examined changes in apathy in HD gene expansion carriers (HDGECs) over 6 years, using a multidimensional measure, and investigated associations with cognition,...Read more

BMJ Case Rep. 2026 Apr 17;19(4):e269215. doi: 10.1136/bcr-2025-269215.ABSTRACTA woman in her 50s with genetically confirmed Huntington's disease presented with right-sided arm sensory symptoms that evolved over days and persisted for at least 1 month. Neurological examination revealed mild right arm hypoesthesia and mild generalised choreiform movements. Brain MRI demonstrated multiple...Read more

Int J Mol Sci. 2026 Apr 4;27(7):3282. doi: 10.3390/ijms27073282.ABSTRACTNeurodegenerative diseases such as Alzheimer's (AD) and Huntington's (HD) remain major therapeutic challenges due to limited treatment efficacy. Imidazoline I2 receptor (I2-IR) ligands have recently emerged as promising neuroprotective agents, with reported roles in modulating oxidative stress, neuroinflammation, and protein aggregation. This...Read more

J Pharm Pharmacol. 2026 Apr 3;78(4):rgag030. doi: 10.1093/jpp/rgag030.ABSTRACTOBJECTIVES: Huntington's disease (HD) is a neurodegenerative condition characterized by a gradual decline in motor skills, cognitive function, and mental health. The 3-nitropropionic acid (3-NPA) model simulates HD-like pathology, which involves calcium dysregulation. To establish a structural basis for targeting Orai-1, in-silico docking...Read more

PLoS One. 2026 Apr 10;21(4):e0346039. doi: 10.1371/journal.pone.0346039. eCollection 2026.ABSTRACTBACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative disease that causes motor (e.g., chorea) and non-motor symptoms (e.g., neurocognitive, neuropsychiatric and autonomic disturbances). Pain is a frequently reported non-motor symptom in HD, with a prevalence of around 40% in the manifest...Read more

Neurobiol Dis. 2026 Jun 1;223:107381. doi: 10.1016/j.nbd.2026.107381. Epub 2026 Apr 6.ABSTRACTHuntington's Disease (HD) is an autosomal dominant neurodegenerative disorder. Recent clinical research has focused on neurofilament light chain protein (NfL), and cholesterol metabolites as potential fluid biomarkers related to disease progression. Our aim was to explore whether the combined longitudinal...Read more