NCBI-Aggregator

Health Expect. 2026 Feb;29(1):e70584. doi: 10.1111/hex.70584.ABSTRACTBACKGROUND: People living with neurological conditions have needs that require an integrated care approach. Existing models of integrated care have often emphasized system structures but neglected the micro-level interactions that matter most to people.OBJECTIVES: To develop a micro-level model for integrated care that represents the...Read more

Brain Behav. 2026 Feb;16(2):e71238. doi: 10.1002/brb3.71238.ABSTRACTPURPOSE: This systematic review examines executive dysfunction in Huntington's disease (HD), an inherited neurodegenerative disorder characterized by cognitive alterations that may emerge years before the onset of motor symptoms. The objective of this review is to provide an updated and comprehensive synthesis of executive function...Read more

Int J Biol Sci. 2026 Jan 1;22(3):1233-1246. doi: 10.7150/ijbs.124552. eCollection 2026.ABSTRACTHuntington's disease (HD) is a rare, inherited neurodegenerative disorder caused by mutations in the huntingtin (HTT) gene. The classic concept is that HD is a degenerative disease that primarily affects the striatum, caused by a gain-of-function mutant mHTT that kills...Read more

Sociol Health Illn. 2026 Feb;48(2):e70149. doi: 10.1111/1467-9566.70149.ABSTRACTThe predictive genetic clinic is a space where counsellors use non-directive counselling to facilitate asymptomatic patients at risk of carrying a dominantly inherited disease access a predictive genetic test. The social science literature has a history of examining practices within this clinic, but with...Read more

Drug Dev Res. 2026 Apr;87(2):e70238. doi: 10.1002/ddr.70238.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative disorder with a poorly understood neurobiological basis. Among the various forms of programmed cell death implicated in neurodegeneration, necroptosis has recently garnered significant attention. Notably, dysregulated necroptosis provokes immune response that drives excessive pro-inflammatory cytokine production, promoting...Read more

J Mol Neurosci. 2026 Jan 19;76(1):11. doi: 10.1007/s12031-025-02463-z.ABSTRACTHuntington's disease (HD) is a rare, inherited neurodegenerative disorder caused by the expanded CAG repeats in the huntingtin gene. The HD domain still lacks detailed knowledge of validated drug targets, limiting the effectiveness of classical methods. To address this gap, we have applied...Read more

Signal Transduct Target Ther. 2026 Jan 19;11(1):23. doi: 10.1038/s41392-025-02545-9.ABSTRACTHuntington's disease (HD) is a fatal neurodegenerative disorder characterized by a triad of behavioral symptoms: involuntary movement, emotional change, and cognitive dysfunction. Although alterations in WNT signaling have been reported in HD, its precise role in pathogenesis remains unclear. In this study,...Read more

Alzheimers Dement. 2026 Jan;22(1):e70944. doi: 10.1002/alz.70944.ABSTRACTBACKGROUND: Cognitive impairments are a hallmark of Huntington's disease (HD).METHODS: Seventy-one participants (43 HD gene-expanded [HDGE], 28 healthy controls) from the HD-Young Adult Study at two timepoints ≈ 4.7 years apart, completed the Cambridge Neuropsychological Test Automated Battery Rapid Visual Information Processing task and underwent...Read more

J Neurol. 2026 Jan 8;273(1):68. doi: 10.1007/s00415-025-13600-4.ABSTRACTHuntington's disease (HD) remains a devastating neurodegenerative disorder caused by CAG repeat expansion in the HTT gene. Biomarkers are urgently needed to facilitate more accurate evaluation of disease onset, progression, and response to interventions. Characteristic clinical features of the disease are secondary to neuronal...Read more

Neurol Sci. 2026 Jan 2;47(1):83. doi: 10.1007/s10072-025-08689-4.ABSTRACTHuntington's disease (HD) is characterized by dementia, delayed psychomotor processes, abnormal choreatic movements, and cognitive impairments. This condition is brought on by an increase in cytosine-adenine-guanine repeats in the huntingtin (Htt) gene on chromosome-4, which produces the Htt protein's poly-glutamine (poly-Q). Despite significant progress...Read more

Orv Hetil. 2025 Dec 28;166(52):2064-2072. doi: 10.1556/650.2025.33430. Print 2025 Dec 28.ABSTRACTThe authors report the case of a patient diagnosed and treated with schizophrenia for nearly 20 years. A rapid change in the neurological status of the patient necessitated a diagnostic revision. The patient's additional medical history included narcolepsy and psoriasis....Read more

Alzheimers Dement. 2025 Dec;21 Suppl 3:e105286. doi: 10.1002/alz70857_105286.ABSTRACTBACKGROUND: Apathy and impulsivity co-occur in Huntington's disease (HD), but these debilitating behavioural syndromes are multidimensional constructs, raising the question of which specific dimensions drive this relationship, and the stability of the co-occurring dimensions across time.METHODS: People with HD and controls completed multidimensional...Read more

Alzheimers Dement. 2025 Dec;21 Suppl 1:e106520. doi: 10.1002/alz70855_106520.ABSTRACTBACKGROUND: Huntington's disease (HD) differs from Alzheimer's disease (AD) in its clinical presentation, particularly regarding vigilance, with notable motor, functional, and cognitive impairments that may be mirrored in resting-state electroencephalographic (rsEEG) rhythms.METHOD: To evaluate this hypothesis, clinical and rsEEG data were gathered from...Read more

Alzheimers Dement. 2025 Dec;21 Suppl 3:e098429. doi: 10.1002/alz70857_098429.ABSTRACTBACKGROUND: Huntington's disease (HD) is marked by progressive cognitive decline, with early deficits often presenting long before motor symptoms. These changes are subtle yet profoundly impactful, underscoring the need for sensitive tools like the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L). The...Read more

Theranostics. 2026 Jan 1;16(5):2388-2404. doi: 10.7150/thno.122651. eCollection 2026.ABSTRACTBackground: Huntington's disease (HD) is a devastating neurodegenerative disorder caused by CAG repeat expansion in the HTT gene, resulting in a polyglutamine-expanded huntingtin (HTT) protein that forms toxic aggregates. Although heat-shock proteins are known to facilitate the refolding or clearance of misfolded proteins,...Read more