NCBI-Aggregator

Biochemistry (Mosc). 2026 Feb;91(2):253-273. doi: 10.1134/S0006297925602850.ABSTRACTMitochondria are semi-autonomous, multifunctional organelles that supply cells with energy. They are highly dynamic structures, capable of moving, fusing, dividing, and forming branched networks. The number, density, and complexity of mitochondrial network are unique to each cell type and reflect cellular demands for ATP and...Read more

Int J Mol Sci. 2026 Mar 4;27(5):2384. doi: 10.3390/ijms27052384.ABSTRACTHuntington's disease (HD) is characterized by progressive striatal atrophy and complex proteomic changes in the central nervous system. Using the ultrasensitive Next-Gen Ultra-Sensitive Immunoassay (NULISA) proteomic platform, we analyzed cerebrospinal fluid (CSF) from 88 persons with HD to dissect the biological correlates...Read more

Proc Natl Acad Sci U S A. 2026 Mar 10;123(10):e2518854123. doi: 10.1073/pnas.2518854123. Epub 2026 Mar 2.ABSTRACTHuntington's disease (HD) is a fatal neurodegenerative disorder caused by inheriting an expanded CAG repeat tract in the huntingtin gene (HTT) that further expands in somatic cells over an individual's lifetime. Genome-wide association studies have...Read more

Int J Nanomedicine. 2026 Feb 20;21:548892. doi: 10.2147/IJN.S548892. eCollection 2026.ABSTRACTHuntington's disease is a progressive neurological disorder marked by motor, cognitive, and psychiatric symptoms. Currently, there are no definitive diagnostic tools or effective treatments to halt or reverse the disease. In recent years, surface-engineered nanosystems have emerged as innovative therapeutic platforms,...Read more

Clin Neurophysiol. 2026 May;185:2111701. doi: 10.1016/j.clinph.2026.2111701. Epub 2026 Feb 12.ABSTRACTOBJECTIVE: To systematically review EEG-based biomarkers in Huntington's disease across resting-state, sleep, medication response, and clinical correlation studies.METHODS: PubMed, Web of Science, and EMBASE databases were systematically searched for studies of sufficient methodological quality that examined EEG alterations in patients with...Read more

Neurotherapeutics. 2026 Jan;23(1):e00859. doi: 10.1016/j.neurot.2026.e00859. Epub 2026 Feb 24.ABSTRACTHuntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease that manifests with progressive motor, cognitive, and psychological impairments. HD is caused by a CAG (glutamine) repeat expansion in the huntingtin (HTT) gene, leading to the misfolding and aggregation of mutant HTT...Read more

Tijdschr Psychiatr. 2026;68(2):82-85.ABSTRACTWe present the case of a 60-year-old woman with Huntington’s disease who was successfully treated with electroconvulsive therapy (ECT) for a recurrent depressive disorder presenting with acute suicidality. Depression is the most common neuropsychiatric disorder in Huntington’s disease and ranks among the most important risk factors for suicide...Read more

JCI Insight. 2026 Feb 23;11(4):e181013. doi: 10.1172/jci.insight.181013. eCollection 2026 Feb 23.ABSTRACTHuntington's disease (HD) is a neurodegenerative disorder caused by the expansion of CAG repeats in the gene encoding huntingtin. Since accumulation of mutant huntingtin (mHtt) leads to dysfunction of numerous cellular pathways and toxicity, reducing levels of the mutant protein...Read more

Exp Neurol. 2026 Jun;400:115700. doi: 10.1016/j.expneurol.2026.115700. Epub 2026 Feb 18.ABSTRACTIn Huntington's disease (HD), reduced neuronal glucose transport plays an important role. We investigated the effects of GLUT3 knock-down (KD) on the trajectory of the HD phenotype in zQ175 model mice. GLUT3 (G3) expression was reduced in heterozygous (HT) and homozygous...Read more

Inflammopharmacology. 2026 Mar;34(3):2027-2038. doi: 10.1007/s10787-026-02146-0. Epub 2026 Feb 20.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative disorder in which neuroinflammation, oxidative stress, and mitochondrial dysfunction are increasingly recognized as important contributors to neuronal vulnerability. Recent evidence indicates that the ATP-gated P2X7 receptor (P2X7R) may participate in coordinating several of these pathological...Read more

J Am Chem Soc. 2026 Mar 4;148(8):8107-8121. doi: 10.1021/jacs.5c14078. Epub 2026 Feb 19.ABSTRACTHuntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the HTT gene, producing mutant huntingtin (mHTT) that misfolds into β-sheet-rich aggregates and drives neuronal loss. Current HTT-lowering strategies face challenges, including invasive...Read more

Trends Mol Med. 2026 Mar;32(3):204-207. doi: 10.1016/j.molmed.2026.01.001. Epub 2026 Feb 14.ABSTRACTHuntington's disease (HD) is usually described as rare, tragic, and intractable. Yet, HD offers a strategically unique entry point for neuroscience. With its genetic clarity, relatively predictable course, and organized global community, HD provides the clearest path to advancing brain...Read more

Neurobiol Dis. 2026 Mar;220:107318. doi: 10.1016/j.nbd.2026.107318. Epub 2026 Feb 11.ABSTRACTWhite matter volume loss has been reported as one of the first indicators in Huntington's disease (HD) patients, but the cellular basis of this deficit remains to be elucidated. To address this, we assessed white matter microstructure in the transgenic R6/1...Read more

Brain Behav. 2026 Feb;16(2):e71149. doi: 10.1002/brb3.71149.ABSTRACTINTRODUCTION: Huntington's disease (HD) is a neurodegenerative disorder characterised by motor dysfunction, cognitive impairment, and psychiatric disturbances. This study analyzed the relationship between clinical characteristics, sarcopenia, and physical activity (PA) levels in HD patients.METHODS: A 1-year observational study was conducted with symptomatic, ambulatory HD patients,...Read more

Health Expect. 2026 Feb;29(1):e70584. doi: 10.1111/hex.70584.ABSTRACTBACKGROUND: People living with neurological conditions have needs that require an integrated care approach. Existing models of integrated care have often emphasized system structures but neglected the micro-level interactions that matter most to people.OBJECTIVES: To develop a micro-level model for integrated care that represents the...Read more