HDBuzz-Aggregator

⏱️ 5 min read | A recent study suggests that strengthening the brain's own clean-up system could slow Huntington’s disease.Read more

⏱️ 5 min read | Prilenia's application for European approval of pridopidine was quietly withdrawn 6 months ago, in November 2025, after the EMA had already recommended refusing the drug. Here's what happened, and why you're only hearing about it now.Read more

⏱️7 min read | A recent study in pigs suggests the HD brain could be under attack from the body's own immune system. The results reveal that invading cytotoxic T cells might contribute to neurodegeneration in HD, suggesting a new therapeutic pathway.Read more

⏱️8 min read | What does “good care” look like in Huntington’s Disease? A new Dutch study asked familial and professional caregivers, and uncovered how differently it’s experienced in practice.Read more

⏱️ 6 min read | While the US regulatory path for AMT-130 remains complicated, uniQure announced plans to seek approval for its HD gene therapy in the UK. Here's what that means, and what might be to come.Read more

⏱️10 min read | PTC Therapeutics shared 2-year data for votoplam, a daily HTT-lowering pill. Stage 2 participants showed up to 52% slowing of disease progression. Here's what the data show, what's still missing, and the roll out of the Phase 3 trial.Read more

⏱️ 8 min read | April 2026 showed us a toxic HTT fragment is center stage in mouse research, CRISPR is showing promise in mouse studies, AI and wearables move closer to the clinic, and 2 studies shine a light on the weight carried by HD caregivers.Read more

⏱️ 10 min read | The Total Functional Capacity score has been used in Huntington’s disease research for decades. Here's what it measures, what it misses, & why it's at the center of an anticipated clinical trial.Read more

⏱️5 min read | Apathy in HD isn’t just “not caring.” It can affect relationships, routines, and emotional connection. A small study of caregivers reveals the heavy toll of apathy and the value of safe spaces to share experiences.Read more

⏱️ 6 min read | HDBuzz is launching Fund the Buzz, our spring fundraising campaign! We're independent, pharma funding-free, and run by scientists who know HD. Help us keep the lights on (and stay lawsuit-free).Read more

⏱️ 6 min read | A new study uses “self-switching” genetic scissors to target the root cause of Huntington’s disease in mice - even after symptoms begin.Read more

⏱️9 min read | From predicting symptom onset to tracking movement changes via smartwatch, artificial intelligence tools are being used in research. Here's where we are, and why Huntington’s disease is a strong candidate for these approaches.Read more

⏱️ 9 min read |New research in a HD mouse model points to a key culprit: a small fragment called HTT1a. Lowering HTT1a levels successfully delayed disease signs in mice that model HD, perhaps shaping the next generation of HTT-lowering therapies.Read more

A small study based in Ireland asked a simple question: what does caring for someone with Huntington’s disease feel like? The answers point to isolation, stigma, and major gaps in healthcare support for many of the respondents.Read more

⏱️ 7 min read | A wrist sensor tracked arm movements in people with HD for a week and could see who had HD and who didn’t. This kind of technology could change how we measure drug effects in trials.Read more

⏱️ 9 min read | March brought us the annual CHDI therapeutics conference along with updates from 3 ongoing clinical trials. We also covered new research on somatic expansion and honored the community that built our science during Gratitude Day.Read more

A new study looking into combined music and physical therapy shows that simple rhythmic cues work better than complex music or instructions, helping to improve movement control and reducing chorea.Read more

⏱️ 6 min read | Today, on Gratitude Day, we share a guest piece from HD researcher Roy Maimon that Huntington's disease is neuroscience's best investment, not just for its scientific clarity, but for the remarkable community built around it.Read more

⏱️ 9 min read | This Gratitude Day, March 23rd, we celebrate the extraordinary partnership between HD families, scientists, and caregivers, and reflect on the place that built the science on which we all stand.Read more

⏱️ 10 min read | In a human cellular system, scientists dialed back mismatch repair genes to reduce CAG expansion by up to 69%. This work is in its early days, but it shows promise for "anti-expansion" therapies that could be used to delay HD onset.Read more

⏱️ 29 min read | Day 3 of the HD Therapeutics Conference dives into breakthrough science, new tools and bold ideas that are pushing HD research toward better treatments.Read more

⏱️ 18 min read | HDBuzz is back with Day 2 of the 21st annual CHDI HD Therapeutics Conference in Palm Springs, CA. We heard about new techniques to zoom in on HD biology in extraordinary detail.Read more

⏱️ 33 min read | HDBuzz is at CHDI's Huntington's Disease Therapeutics Conference, ready to bring you live updates from the most recent research in the field. Get ready for some exciting science!Read more

⏱️ 8 min read | An oral Huntington's disease drug is eligible for accelerated approval in Australia. This isn't full approval yet, but it opens a faster path to potentially getting this once-daily pill to people with HD sooner.Read more

The FDA wants more data before approving AMT-130 for Huntington’s disease in the U.S. On March 2026, uniQure shared in an update that current Phase 1/2 data weren’t enough for the agency. A new randomized, sham-controlled trial may be required.Read more

⏱️ 6 min read | Vico Therapeutics' Huntington’s disease drug VO659 is now being tested just twice a year, and the FDA has cleared the way for US trials to begin later this year.Read more

⏱️ 8 min read | February 2026 HD research recap: published trial data from branaplam trial; new insights into the genetics of the HD "grey zone"; plus worms, brain circuits, eye tracking, and the hidden psychological weight of living at risk.Read more

A new review from the University of Cambridge explores ocular biomarkers in HD, including retinal scans and eye movement tracking.Read more

⏱️ 8 min read | Your brain is an advanced supercomputer. But in HD, a core processor starts to malfunction. A research group at UCLA has taken a close look to visualize the specific circuits going haywire – and how they look different in HD.Read more