Downloads – Mouse Allelic Series

Mouse Allelic Series

A longitudinal mouse in-vivo project developed collaboratively between MGH, Psychogenics (PGI) and CHDI. See publications:

• Langfelder, P., Cantle, J.P., Chatzopoulou, D., Wang, N., Gao, F., , Al-Ramahi, Lu, X.H., Ramos, E.M., El-Zein, K., Zhao, Y., Deverasetty, S., Tebbe, A., Schaab, C., Lavery, D.J., Howland, D., Kwak, S., Botas, J., Aaronson, J.S., Rosinski, J., Coppola, G., Horvath, S., and Yang, X.W. Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice, Nat Neurosci., 19, 623–633 (2016).
• Alexandrov, V., Brunner, D., Menalled, L.B., Kudwa, A., Watson-Johnson, J., Mazzella, M., Russell, I., Ruiz, M.C., Torello, J., Sabath, E., Sanchez, A., Gomez, M., Filipov, I., Cox, K., Kwan, M., Ghavami, A., Ramboz, S., Lager, B., Wheeler, V.C., Aaronson, J., Rosinski, J., Gusella, J.F., MacDonald, M.E., Howland, D., and Kwak, S. Large-scale phenome analysis defines a behavioral signature for Huntington’s disease genotype in mice, Nat Biotechnol., (2016) 
• Langfelder P, Gao F, Wang N, Howland D, Kwak S, Vogt TF, Aaronson JS, Rosinski J, Coppola G, Horvath S, Yang XW. MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice. PLoS One. 2018 Jan 11;13(1):e0190550.