HDinHD: Open Source Science for the HD Research Community
The goal of HDinHD is to foster and support a collaborative community united in its drive to accelerate the development of therapeutics that will delay the onset and/or ameliorate the effects of Huntington’s disease. HDinHD seeks to achieve this through:
- Sharing HD-related primary scientific data
- Sharing analyses and computational models built from HD-related scientific data
- Providing browsing and data interrogation tools over both primary and analyzed data that facilitate data exploration and hypothesis generation
- Building a forum for HD researchers to highlight their data, tools, know-how and insight to the community
The HDinHD website – founded as a partnership between CHDI and the Coppola Lab at UCLA – is currently a joint development effort by CHDI, Bridlewood Consulting and Rancho BioSciences. As you will see when you Register for access, HDinHD highlights data and tools provided by the broader community. If you are interested in Contributing Data to HDinHD, suggest links to other HD-related scientific data or websites, or would otherwise like to provide Feedback to us, we encourage you to do so. HDinHD is for the community; please help us tailor and grow HDinHD in a direction that can make a difference to your research, and ultimately, to improve the lives of HD families.
Want to learn more about HDinHD?
| Watch a detailed video overview of HDinHD presented at the 16th Annual HD Therapeutics Conference (April 2021). The video outlines data resources and tools within HDinHD and provides a detailed demonstration of the new HD Explorer tool. |
Read the following publication introducing HDinHD: HDinHD: A Rich Data Portal for Huntington’s Disease Research, J Huntingtons Dis., 10, 405-412
Latest news and publications from around the HD Ecosystem
HDBuzz
- A road less traveled: how making less huntingtin can alter somatic instability and may delay symptoms
- A tug-of-war at the DNA: how Huntington’s repeats grow and shrink
- UniQure Receives FDA Meeting Minutes on AMT-130 While Community Support Remains Strong
- Feeding the Brain Through the Gut: How Prebiotics Might Shape Huntington’s Disease
- An Old Drug, New Tricks: Sertraline May Lighten the Load in HD by Targeting Protein Production
Literature
- Post-Translational Modifications of Huntingtin: Mechanistic Insights and Therapeutic Opportunities in Huntington's Disease
- Sigma-2 Receptor Antagonism Enhances the Neuroprotective Effects of Pridopidine, a Sigma-1 Receptor Agonist, in Huntington's Disease
- Endothelial NLRP3-mediated pyroptosis induces blood-brain barrier and neuronal damage in Huntington's disease models
- Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding
- Huntington's Disease and Psychiatric Comorbidities: A Retrospective Study in Portugal
News
- 2025 Has Been a Year of Unraveling Progress in Health - Time Magazine
- Ophidion, Inc. and Neuronasal, Inc. Announce Strategic Collaborations to Tackle ... - Business Wire
- how making less huntingtin can alter somatic instability and may delay symptoms - HDBuzz
- The biggest scientific breakthroughs of the last 25 years—and a few to watch
- Dr Mena Farag awarded a UK DRI Recognition Prize 2025 | UCL Faculty of Brain Sciences




