Data Decompression
All of the HDinHD datasets are made available as either compressed files or tar archives (GNU tar, GNU gzip). On most Macintosh and Linux computers, tools are available to decompress these files. On Windows computers, you may need to download and install a decompression application. We recommend either WinZip or 7-Zip.
DNA Repair & Handling
There is growing evidence from genome-wide association studies in people and experimental testing in model systems that DNA damage is not only a consequence of but also is a significant contributor to the development of neurodegenerative diseases such as Huntington’s Disease. DNA repair pathways play an important role in the maintenance of both nuclear and mitochondrial DNA integrity in neurons and other cell types. Understanding the signaling pathways involved in neuronal DNA damage response is critical to interrogating this mechanism. CHDI has engaged Clarivate Analytics to explore the state of the scientific literature (up to 2016) to identify and articulate the genes and pathways involved in DNA Damage Response and Repair with a special emphasis on the effect in Huntington’s Disease and other trinucleotide repeat disorders.
